| Dr. Bones | 1 | Human |
| Dr. Bones | 1 | Human |
| Dr. Christina Bryan | 1 | Human |
| Dr. Emerson Hale | 1 | Human |
| Dr. Emerson Hale | 1 | Human |
| Dr. Killroy | 0.1 | SentryBot |
| Dr. Song | 1 | Human |
| Drifter | 100 | Drifter |
| Drill | 21 | Mothman |
| Drill Progress | 21 | Mothman |
| Duchess | 6 | Human |
| Duncan McKann | 6 | Human |
| Dusky Yao Guai | 66 | Yao Guai |
| Dust Devil | 1 | Dust Devil |
| Dylan Rhodes | 66 | Human |
| Earle Williams | 6 | Human |
| EBS Voice | 1 | Human |
| Eddie Nelson | 66 | Human |
| Edie Bachmann | 1 | Human |
| Eightball | 66 | Human |
| Elder Pepper | 1 | Human |
| Elder Roger Maxson | 1 | Human |
| Elite Rapidan Assaultron | 100 | Assaultron |
| Eliza | 1 | Human |
| Ella Ames | 6 | Human |
| Elsie Taylor | 66 | Human |
| Emergency Technician Repair Bot | 3 | Mr. Handy |
| EMIAC the False | 50 | Robobrain |
| Emperor Radscorpion | 100 | Radscorpion |
| EN06 Guardian | 0.1 | Guardian Bot |
| Enclave Corpse | 6 | Human |
| Enclave Heavy Laser Turret | 25 | Enclave Turret |
| Enclave Heavy Machinegun Turret | 15 | Enclave Turret |
| Enclave Laser Turret | 6 | Enclave Turret |
| Enclave Machinegun Turret | 4 | Enclave Turret |
| Enclave Missile Turret | 28 | Enclave Turret |
| Enclave Polished Steel Heavy Laser Turret | 25 | Enclave Turret |
| Enclave Polished Steel Heavy Machinegun Turret | 15 | Enclave Turret |
| Enclave Polished Steel Laser Turret | 6 | Enclave Turret |
| Enclave Polished Steel Machinegun Turret | 4 | Enclave Turret |
| Enclave Polished Steel Missile Turret | 28 | Enclave Turret |
| Enclave Polished Steel Shotgun Turret | 20 | Enclave Turret |
| Enclave Repair Bot | 3 | Protectron |
| Enclave Sentry Bot | 0.1 | SentryBot |
| Enclave Sentry Bot | 0.1 | SentryBot |
| Enclave Shotgun Turret | 20 | Enclave Turret |
| Encrypted Transmission | 6 | Human |
| Engineer | 1 | Human |
| Engineer | 1 | Human |
| Engineer | 8 | Mr. Handy |