| Enraged Fog Crawler | 63 | Fog Crawler |
| Enraged Grafton Monster | 30 | Grafton Monster |
| Enraged Mole Miner | 95 | Mole Miner |
| Enraged Mole Miner | 95 | Mole Miner |
| Enraged Mole Rat Landminer | 95 | Mole Rat |
| Enraged Old Lady | 100 | Ghoul |
| Epic Behemoth | 65 | Behemoth |
| Ernesto | 8 | Mr. Handy |
| Ernie Navarro | 1 | Ghoul |
| Erratic Radstag | 21 | Radstag |
| Erratic Radstag Doe | 12 | Radstag |
| Escaped Inmate | 6 | Human |
| Esme Rousseau | 66 | Human |
| Estella | 8 | Mr. Handy |
| Eta Psi Protectron | 5 | Protectron |
| Eugene | 66 | Human |
| Eugene | 1 | Human |
| Eugenie | 0.1 | Ghoul |
| Eugenie | 0.1 | Ghoul |
| Evelyn Russo | 66 | Human |
| Evidence Collection Assistant Collectron | 3 | Protectron |
| Ex-Raider | 6 | Human |
| Executive R. Vargas | 6 | Mirelurk Spawn |
| Extra Crispy Scorchbeast | 50 | Scorchbeast |
| EyeBomb | 1 | EyeBot |
| EyeBomb | 1 | EyeBot |
| EyeBomb Suicider | 1 | EyeBot |
| EyeBot | 1 | EyeBot |
| EyeBot | 1 | EyeBot |
| EyeBot | 1 | EyeBot |
| EyeBot | 1 | EyeBot |
| EyeBot | 1 | EyeBot |
| EyeBot | 1 | EyeBot |
| EyeBot | 1 | EyeBot |
| EyeBot | 1 | EyeBot |
| EyeBot | 1 | EyeBot |
| EyeBot | 1 | EyeBot |
| EyeBot | 60 | EyeBot |
| EyeBot | 1 | EyeBot |
| EyeBot | 1 | EyeBot |
| EyeBot | 1 | EyeBot |
| EyeBot | 1 | EyeBot |
| EyeBot Guard | 1 | EyeBot |
| F.E.T.C.H. Collectron | 3 | |
| Fabio Mondadori | 1 | Human |
| Fabled Flatwoods Monster | 40 | Flatwoods Monster |
| Fake Player | 1 | Human |
| Fake Player 01 | 66 | Ghoul |
| Fanatic | 1 | Human |
| Fanatic | 1 | Human |