| Crossbow | 6 | 50 | 15–45 | Bows |
| Crossbow | 6 | 50 | 15–45 | Bows |
| Crowd Control | 7 | 125 | 40–50 | BallisticShotguns |
| crRailway Rifle | 9 | 90 | 30–50 | BallisticRifles |
| Crusader Pistol | 3 | 40 | 30–50 | BallisticPistols |
| Crushing Blow | 6 | 30 | 45 | BallisticExplosiveBig guns |
| Cryo Alien Blaster | 2 | 90 | 20–50 | EnergyPistols |
| Cryo Alien Blaster | 2 | 90 | 20–50 | EnergyPistols |
| Cryo Alien Blaster | 2 | 90 | 20–50 | EnergyPistols |
| Cryo Arm Cannon | 2 | 0 | | |
| Cryo Mine | 0.7 | 30 | | Explosive |
| Cryogenic Grenade | 0.75 | 25 | | ExplosiveCryoThrowing |
| Cryogenic Grenade | 0.5 | 25 | | Explosive |
| Cryolator | 10 | 145 | 25–45 | EnergyBig guns |
| Cryolator | 30 | 0 | | BallisticPistols |
| Cryolator | 30 | 0 | | BallisticPistols |
| Cryolator | 10 | 145 | 25–45 | BallisticEnergyBig guns |
| Cryolator | 10 | 250 | 1–50 | BallisticEnergyBig guns |
| Cultist Blade | 3 | 35 | 10–50 | One-handed melee |
| Cultist Blade | 3 | 35 | 10–50 | One-handed melee |
| Cultist Blade | 3 | 35 | 10–50 | One-handed melee |
| Cultist Blade | 3 | 35 | 10–50 | One-handed melee |
| Cultist Dagger | 1 | 40 | 15–45 | One-handed melee |
| Cultist Dagger | 1 | 40 | 15–45 | One-handed melee |
| Cultist Dagger | 1 | 40 | 15–45 | One-handed melee |
| Daring Binoculars | 1 | 100 | 1 | |
| Death Tambo | 0.5 | 60 | 15–45 | Fist weapons |
| Death Tambo | 0.5 | 60 | 15–45 | Fist weapons |
| Death Tambo | 0.5 | 60 | 15–45 | Fist weapons |
| Deathclaw Gauntlet | 10 | 85 | 30–50 | Fist weapons |
| Deathclaw Gauntlet | 10 | 85 | 30–50 | Fist weapons |
| Deathclaw Gauntlet | 10 | 85 | 30–50 | Fist weapons |
| Disorderly Conduct | 2 | 15 | 45 | One-handed melee |
| DLC01BotWeapRobobrainSmokeBombLeft | 3 | 0 | | |
| DLC01BotWeapRobobrainSmokeBombLeft | 3 | 0 | | |
| DLC01BotWeapRobobrainSmokeBombRight | 3 | 0 | | |
| DLC01BotWeapRobobrainSmokeBombRight | 3 | 0 | | |
| DLC04AnimatronicLaserGunMkVII | 25 | 0 | | Energy |
| Doctor's Orders | 6 | 40 | 40–50 | BallisticRifles |
| Dom Pedro | 5.5 | 25 | 20–50 | Ballistic |
| Double-Barrel Shotgun | 6 | 100 | 15–45 | BallisticShotguns |
| Double-Barrel Shotgun | 6 | 100 | 15–45 | BallisticShotguns |
| Double-Barrel Shotgun | 6 | 100 | 15–45 | BallisticShotguns |
| Double-Barrel Shotgun | 6 | 100 | 15–45 | BallisticShotguns |
| Double-Barrel Shotgun | 6 | 100 | 15–45 | BallisticShotguns |
| Double-Barrel Shotgun | 6 | 100 | 15–45 | BallisticShotguns |
| Double-Barrel Shotgun | 6 | 100 | 15–45 | BallisticShotguns |
| Double-Barrel Shotgun | 6 | 100 | 15–45 | BallisticShotguns |
| Drill | 2 | 80 | 20–50 | One-handed melee |
| Drill | 2 | 80 | 20–50 | One-handed melee |