| Sheepsquatch Shard | 0.15 | 15 | | Throwing |
| Sheepsquatch Staff | 12 | 40 | 10–50 | Two-handed melee |
| Shepherd's Crook | 2 | 45 | 10–50 | Two-handed melee |
| Shishkebab | 3 | 120 | 35–45 | FireOne-handed melee |
| Shishkebab | 3 | 0 | | One-handed melee |
| Shishkebab | 3 | 0 | | One-handed melee |
| Shishkebab | 3 | 120 | 5–45 | FireOne-handed melee |
| Shishkebab | 3 | 120 | 5–45 | FireOne-handed melee |
| Shishkebab | 3 | 120 | 35–45 | FireOne-handed melee |
| Shovel | 6 | 40 | 1–45 | Two-handed melee |
| Shovel | 6 | 40 | 1–45 | Two-handed melee |
| Shovel | 6 | 40 | 1–45 | Two-handed melee |
| Shovel | 6 | 40 | 1–45 | Two-handed melee |
| Sickle | 3 | 15 | 1–50 | One-handed melee |
| Sickle | 3 | 15 | 1–50 | One-handed melee |
| Sickle | 3 | 15 | 1–50 | One-handed melee |
| Sickle | 3 | 15 | 1–50 | One-handed melee |
| Sickle | 3 | 15 | 1–50 | One-handed melee |
| Single Action Revolver | 4 | 85 | 10–50 | BallisticPistols |
| Single Action Revolver | 4 | 85 | 10–50 | BallisticPistols |
| Single Action Revolver | 4 | 85 | 10–50 | BallisticPistols |
| Single Shot Ver 1 | 3 | 0 | | |
| Single Shot Ver 2 | 3 | 0 | | |
| Ski Sword | 3 | 40 | 15–45 | One-handed melee |
| Slay Bells | 0.5 | 60 | 15–45 | Fist weapons |
| Sledgehammer | 12 | 40 | 10–50 | Two-handed melee |
| Sledgehammer | 12 | 40 | 10–50 | Two-handed melee |
| Sledgehammer | 12 | 40 | 10–50 | Two-handed melee |
| Sledgehammer | 12 | 40 | 10–50 | Two-handed melee |
| Sledgehammer | 12 | 40 | 10–50 | Two-handed melee |
| Sledgehammer | 12 | 40 | 10–50 | Two-handed melee |
| Sledgehammer | 12 | 40 | 10–50 | Two-handed melee |
| Sledgehammer | 12 | 40 | 10–50 | Two-handed melee |
| Sledgehammer | 12 | 40 | 10–50 | Two-handed melee |
| Sledgehammer | 12 | 40 | 10–50 | Two-handed melee |
| Sledgehammer | 12 | 40 | 10–50 | Two-handed melee |
| Slug Buster | 3 | 85 | 45 | Energy |
| Smoke Grenade | 0.5 | 15 | | ExplosiveThrowing |
| Snallygaster Spit Attack | 3 | 0 | | |
| Sole Survivor | 6 | 135 | 45 | BallisticRifles |
| Sole Survivor | 6 | 135 | 25–45 | BallisticRifles |
| Sonic Attack | 3 | 0 | | |
| Space Sentry Bot Left Auto Laser | 3 | 0 | | EnergyBig guns |
| Space Sentry Bot Left Auto Laser | 3 | 0 | | EnergyBig guns |
| Space Sentry Bot Left Auto Laser | 3 | 0 | | EnergyBig guns |
| Space Sentry Bot Left Auto Laser | 3 | 0 | | Big guns |
| Space Sentry Bot Right Auto Laser | 3 | 0 | | EnergyBig guns |
| Space Sentry Bot Right Auto Laser | 3 | 0 | | EnergyBig guns |
| Space Sentry Bot Right Auto Laser | 3 | 0 | | EnergyBig guns |
| Space Sentry Bot Right Auto Laser | 3 | 0 | | Big guns |