| Soap | 0.5 | 4 | 8 |
| Sodium Cyanide Canister | 2 | 0 | 0 |
| Sol's Transmitter | 0 | 0 | |
| Soldier's Remains | 0 | 0 | |
| SolLoc_ContItem_Template | 1 | 0 | 0 |
| Solvent Attractant | 1.5 | 0 | 0 |
| Solvent Deterrant | 1.5 | 0 | 0 |
| Solvent Enhancer | 1.5 | 0 | 0 |
| Solvent Suppressor | 1.5 | 0 | 0 |
| Souvenir Coffee Cup | 0.5 | 1 | 2 |
| Souvenir Drinking Glass | 0.5 | 1 | 2 |
| Souvenir Magnet Cow | 0.2 | 3 | 15 |
| Souvenir Plastic Bowl | 0.5 | 2 | 4 |
| Souvenir Sloth Toy | 1 | 9 | 9 |
| Souvenir Toy Car | 1 | 7 | 7 |
| Space Cow Flair | 0.01 | 0 | 0 |
| Spatula | 0.5 | 3 | 6 |
| Spatula | 0.5 | 3 | 6 |
| Specimen Jar | 0.5 | 2 | 4 |
| Speckled Alotolotl Plushie | 0.01 | 0 | 0 |
| Speckled Axolotl Flair | 0.01 | 0 | 0 |
| Speech Bobblehead - DEPRECATED | 0 | 300 | |
| Spiked Heavy Sledgehammer Mod | 1 | 25 | 25 |
| Spiked Knuckles Mod | 1 | 25 | 25 |
| Spiked Lead Pipe Mod | 1 | 25 | 25 |
| Spiked Paddle Ball | 1 | 25 | 25 |
| Spiked Pool Cue Mod | 1 | 25 | 25 |
| Spiked Rocket Heavy Sledgehammer Mod | 1 | 28 | 28 |
| Spiked Rolling Pin Mod | 1 | 25 | 25 |
| Spiked Walking Cane Mod | 1 | 25 | 25 |
| Spin The Wheel Snow Globe | 0.01 | 0 | 0 |
| Spine | 1 | 5 | 5 |
| Spooky Mr. Fuzzy Pencil | 0.2 | 3 | 15 |
| Spooky Time Mr. Fuzzy | 0.6 | 7 | 11.7 |
| Spotted Alotolotl Plushie | 0.01 | 0 | 0 |
| Spotted Axolotl Flair | 0.01 | 0 | 0 |
| Squirrel Flair | 0.01 | 0 | 0 |
| Stabilized | 1 | 25 | 25 |
| Stabilized | 0 | 15 | |
| Stabilizer Coil | 0 | 0 | |
| Stable Cobalt Flux | 1 | 100 | 100 |
| Stable Crimson Flux | 1 | 100 | 100 |
| Stable Fluorescent Flux | 1 | 100 | 100 |
| Stable Violet Flux | 1 | 100 | 100 |
| Stable Yellowcake Flux | 1 | 100 | 100 |
| Stack of Gold Bullion | 0 | 0 | |
| Stalker Plushie | 0.01 | 0 | 0 |
| Standard | 1 | 25 | 25 |
| Standard | 1 | 25 | 25 |
| Standard | 1 | 25 | 25 |