| Plan: Siren | Vendor Bot Bob, Vendor Bot Responder |
| Plan: Sitting Gorilla | Holiday Scorched |
| Plan: Skeleton Costume | Random Encounter: Dead Trick-or-Treater, Mutated Public Events |
| Plan: Ski Sword | Free States vendor, Grahm, Shopping Mall vendor, Vendor Bot Wallace, Watoga Vendor Bot |
| Plan: Ski Sword Skate Blade | Mutated Public Events |
| Plan: Skiing Outfit | Mutated Public Events |
| Plan: Skull Rider Helmet | Unknown |
| Plan: Skyfire Float | Fishing Challenge: Catch All Fish in Skyline Valley x4 |
| Plan: Slab of Ground Meat Plushie | Unknown |
| Plan: Slab of Steak Plushie | Unknown |
| Plan: Sledge Hammer | Grahm |
| Plan: Sledgehammer Heavy Spiked Rocket | Mutated Public Events |
| Plan: Slocum Joe's Power Armor Paint | Minerva |
| Plan: Slot Machine Podiums | Expedition: Tax Evasion, Giuseppe Della Ripa |
| Plan: Slumber Mill Motel Sign | Unknown |
| Plan: Small Backpack | Overseer's Cache, Morgantown Airport |
| Plan: Small Glazed Pot | Unknown |
| Plan: Small Letters Set | Event: Claim Workshop |
| Plan: Small Supply Crate | Unknown |
| Plan: Small Tent | Unknown |
| Plan: Small Vault Girl Statue | Unknown |
| Plan: Smart Frag Grenade | Unknown |
| Plan: Smoke Grenade | Unknown |
| Plan: Snake Wrangler Hat | Expedition: The Most Sensational Game, Giuseppe Della Ripa |
| Plan: Snake Wrangler Outfit | Expedition: The Most Sensational Game, Giuseppe Della Ripa |
| Plan: Snallygaster Plushie | Unknown |
| Plan: Snow Globe: Camp Liberty | Holiday Scorched |
| Plan: Snow Globe: Dark Hollow Manor | Holiday Scorched |
| Plan: Snow Globe: High Knob Lookout | Holiday Scorched |
| Plan: Snow Globe: Shenandoah Visitor Center | Holiday Scorched |
| Plan: Snow Globe: Slumber Mill Motel | Holiday Scorched |
| Plan: Snowman Head Backpack Flair | Holiday Scorched |
| Plan: Socialite Outfit | Unknown |
| Plan: Solar Armor Chest Piece | Minerva, Reginald Stone |
| Plan: Solar Armor Left Arm | Minerva, Reginald Stone |
| Plan: Solar Armor Left Leg | Minerva, Reginald Stone |
| Plan: Solar Armor Right Arm | Minerva, Reginald Stone |
| Plan: Solar Armor Right Leg | Minerva, Reginald Stone |
| Plan: Sole Survivor | Daily Ops; Minerva |
| Plan: Solomon Hardy | Unknown |
| Plan: Soundmaker | Unknown |
| Plan: Spear | Unknown |
| Plan: Specimen Jar | Unknown |
| Plan: Spectacular Performer's Headwear | Unknown |
| Plan: Spectacular Performer's Outfit | Unknown |
| Plan: Speed Bag | Unknown |
| Plan: Spicy Tenderizer Mod | Quest: Grahm's Meat-Cook, Event: Meat Week |
| Plan: Spiked Electro Enforcer | Event: Invaders from Beyond |
| Plan: Spiked Shepherd's Crook | Event: Free Range |
| Plan: Spiked Walking Cane | Mutated Public Events |